Personal commentary on the news shaping metabolic medicine.
Clear, evidence-based commentary on the news shaping metabolic medicine — from a physician with 15+ years in the clinic and in trials.
Recent articles
Remission of obesity: lifelong therapy, or restored body composition and metabolic flexibility?
Can you imagine a time when obesity is in remission? And if so, what would that remission look like?
20 Oct 2026 CKM syndromeThe "atomic model" of CKM syndrome
Deconstructing cardiovascular-kidney-liver-metabolic syndrome as an "atomic structure."
14 Apr 2026 New therapiesA fixed-dose combination of GLP-1 and SGLT2 in a tablet
Fixed-dose combinations of oral GLP-1 RAs with other glucose-lowering agents in development.
30 Nov 2025 ObesityGLP-1, GIP, amylin, glucagon – "mix and match" approach
How are unimolecular multi-agonists compared with therapeutic cocktails of nutrient-stimulated hormones?
29 Nov 2025 ObesityAt the intersection of pain and obesity
It’s intriguing to see the reintegration of pain signaling pathways into obesity therapeutics at a conceptual level.
29 Nov 2025 ObesityMental health role in obesity management
I have added 𝗺𝗲𝗻𝘁𝗮𝗹 𝗵𝗲𝗮𝗹𝘁𝗵 (brain) to the EASO’s framework of obesity management.
9 Nov 2025 Cross-organ TalkHypothalamic inflammation and obesity
A new review by Sebastián Zagmutt Caroca et al positions chronic hypothalamic microinflammation as an initiating event, not a downstream consequence, of systemic metabolic dysfunction and obesity.
9 Nov 2025 ObesityObesity management and Individualization of therapy
These are the two most complementary infographics from the European Association for the Study of Obesity (EASO) and the American Association of Clinical Endocrinology (AACE).
2 Nov 2025 Cross-organ TalkCross-Talk Between Organs in the Human Body
Organ cross-talk represents the complex reciprocal communication between distant organs mediated by various signaling factors.
29 Sep 2025 ObesityObesity paradox, or Pandora’s box of Obesity
‘Visceral silence‘ makes room for mental food noise – this is one the paradoxes of obesity, which could be described as Pandora’s box.
17 Sep 2025 Cross-organ TalkBrain-liver axis
When I combine these findings with the work of Prof. Brüning and his colleagues on the central regulation of the hypothalamus–liver axis, it gives the impression that FGF1 functions as a postprandial regulator of this axis.
18 May 2025