A new review by Sebastián Zagmutt Caroca et al positions chronic hypothalamic microinflammation as an initiating event, not a downstream consequence, of systemic metabolic dysfunction and obesity: “The hypothalamus plays a central role in regulating energy balance, and its dysfunction is a key contributor to the development of metabolic diseases such as obesity and type…

Organ cross-talk represents the complex reciprocal communication between distant organs mediated by various signaling factors. In other words, most of our organs are multilingual. This communication system involves cellular pathways, soluble mediators, and neurohormonal actions that maintain whole-body homeostasis. The foundational elements of inter-organ communication consist of closed-loop feedback mechanisms employing either stimulatory or inhibitory…

FGF21 reverses MASH through coordinated actions on the CNS and liver – ScienceDirect When I combine these findings with the work of Prof. Brüning and his colleagues on the central regulation of the hypothalamus–liver axis (https://lnkd.in/embCm_9x), it gives the impression that FGF1 functions as a postprandial regulator of this axis. It appears to be secreted…