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Organ cross-talk represents the complex reciprocal communication between distant organs mediated by various signaling factors. In other words, most of our organs are multilingual. This communication system involves cellular pathways, soluble mediators, and neurohormonal actions that maintain whole-body homeostasis. The foundational elements of inter-organ communication consist of closed-loop feedback mechanisms employing either stimulatory or inhibitory…
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When the Energy Balance Box Doesn’t Fit: Out-of-the-Box Thinking for Obesity. The energy imbalance simplification is wrong. Explaining obesity pathogenesis solely through the energy balance lens is a reductionist view. Plenty of publications have been written here on this topic, yet the final drop still hasn’t fallen to sink the energy imbalance theory of obesity.…
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FGF21 reverses MASH through coordinated actions on the CNS and liver – ScienceDirect When I combine these findings with the work of Prof. Brüning and his colleagues on the central regulation of the hypothalamus–liver axis (https://lnkd.in/embCm_9x), it gives the impression that FGF1 functions as a postprandial regulator of this axis. It appears to be secreted…